Department of Biochemistry & Molecular Biology

Academic publishing


  1. Phan Tuan Nghia and Nguyen Thi Hong Loan (2013). HIV and HIV protease. Natural Science and Technology Publishing House.193 pp.
  2. Phan Tuan Nghia (2012) Experimental Biochemistry, Vietnam Education Publishing House. 167 pp
  3. Pham Tran Chau and Phan Tuan Nghia (2006). Enzymes and applications, Vietnam Education Publishing House. 199 pp.
  4. Nguyen Quang Vinh, Bui Phuong Thuan and Phan Tuan Nghia (2004). Experiments of Biochemistry, Publishing house: Vietnam National University, Hanoi, 129 pp.

Patents and utility solutions

  1. Utility solution: Specific peptide substrates for HIV-1 protease activity assay, Authors:  Dr. Nguyen Thi Hong Loan and Prof. Dr. Phan Tuan Nghia. Certificate: 2333, (2020), Department of Intellectual Properties of Vietnam.
  2. Utility solution: Procedure for production of catalase from Beef liver, Authors: Dr. Đinh Nho Thái and Dr. Nguyen Thi Hong Loan. Certificate: 2325 (2020) Department of Intellectual Properties of Vietnam.
  3. Pantent: Kit for determination of point matations of human mitochondrial genome and procedure for kit production, Main author: Prof. Dr. Phan Tuan Nghia. Certificate: 21453 (2019), Department of Intellectual Properties of Vietnam.
  4. Utility solution: Kit for DNA and RNA isolation from paraflm-embeded samples and procedure for kit production, Co-author: Prof. Dr. Phan Tuan Nghia. Certificate: VN-2-0002116, (2019). Department of Intellectual Properties of Vietnam.
  5. Utility solution: Procedure for production of TCD4+ and TCD8+ lymphocyte counting kit, Co-author: Prof. Dr. Phan Tuan Nghia, Certificate: 1640 (2018), Department of Intellectual Properties of Vietnam.
  6. Utility solution: Kit for Mycobacterium tuberculosis DNA isolation and procedure for kit production, Co-author: Prof. Dr. Phan Tuan Nghia, Certificate: 1780 (2018), Department of Intellectual Properties of Vietnam.
  7. Utility solution: Procedure for standard DNA samples for detection of point mutations of human mitochondrial genome. Main author: Prof. Dr. Phan Tuan Nghia, Certificate: 1894 (2018), Department of Intellectual Properties of Vietnam.

Selected publications (in the last five years)

  1. Nguyen T. Bich-Loan, Kieu T. Kien, Nguyen L. Thanh, Nguyen T. Kim-Thanh, Nguyen Q. Huy, Pham The-Hai, Marc Muller, Amandine Nachtergael, Pierre Duez, Nguyen D. Thang, Toxicity and anti-proliferative properties of Anisomeles indica ethanol extract on cervical cancer Hela cells and zebrafish embryos, Life 2021, 11(3), 257.
  2. Nguyen TT, Nguyen HT, Pham HTT, Nguyen HA, Phan TN, Hara T, Takatsuka Y, Nguyen TVA (2020), Cooperative improvement in growth rate, red‐colour score, and astaxanthin level of white‐leg shrimp by Bacillus strains originating from shrimp gut. J. Appl.Microbiol. Doi: 10.1111/jam.14603.
  3. Nguyen Thi Le Na, Bui Thi Van Khanh, Pham Xuan Huy, Hoang Thi My Nhung, Nguyen Dinh Thang. Melanin biomaterial effectively eliminates bacteria from water and synergistically induces melanoma-cell death during X-ray irradiation. Materials technology. 2020, 36 (5), 261-269.
  4. Hai Pham The, Phuong Ha Vu, Thu Thuy Thi Nguyen, Ha Viet Thi Bui, Huyen Thanh Thi Tran, Hanh My Tran, Huy Quang Nguyen, Byung Hong Kim, 2019. A laboratory-scale study of the applicability of a halophilic sediment bioelectrochemical system for in situ reclamation of water and sediment in brackish aquaculture ponds: Effect of operational conditions on performance. Journal of Microbiology and Biotechnology 29: 1607-1623.
  5. Tao Vu, Ha Vu, Giang Nguyen, Hanh-Dung Thai, Hien Vu, Hien Pham, Linh Mai, Huyen Tran, Ngoc Pham, Diep Le, Huy Nguyen, Van-Tuan Tran, 2019. A newly developed Agrobacterium-mediated genetic manipulation system revealed more about the function of the global regulator LaeA in Penicillium chrysogenum, Fungal Biology 123: 830-842
  6. Nguyen Dinh Thang*, Le Dinh Tu, Nguyen Thi Le Na, Ngo Thi Trang, Phan Tuan Nghia. Melanin-containing feed stuffs protect Litopenaeus vannamei from white spot syndrome virus. Int Aquat Res (2019) 11: 303.
  7. Nguyen Thi Bich Loan, Ngo Ngoc Trung, Nguyen Thi Le Na, Nguyen Dinh Thang*. Anticancer activities of ricin-liposome complexes on SKMEL-28 cells. Asian Pac J Cancer Prev. 2019 Jul 1;20(7):2117-2123.
  8. H.T. Dung Nguyen, B. Ngoc Nguyen, T.P. Linh Nguyen, T. Ly Do, T. Tung Nguyen, H. Nam Nguyen, Sakurai Kazuo, Mochizuki Shinichi, Kihara Takanori, D. Thang Nguyen, T.V. Anh Nguyen, T.T. Huong Pham. An Agarose-Curdlan Nanogel carries Etanercept to Target and Neutralise TNF-α Produced by Dectin-1-Expressing Immune Cells. Journal of Electronic Materials, 2019, 48 (10), 6570-6582.
  9. Le Na NT, Duc Loc S, Minh Tri NL, Bich Loan NT, Anh Son H, Linh Toan N, Phuong Thu H, My Nhung HT, Lai Thanh N, Van Anh NT, Dinh Thang N*. Nanomelanin Potentially Protects the Spleen from Radiotherapy Associated Damage and Enhances Immunoactivity in Tumor-Bearing Mice. Materials (Basel). 2019 May 27;12(10).
  10. Van-Dung Nguyen, Hong-Loan Thi Nguyen ̧ Linh-Chi Do, Vu Van Tuan, Phuong Thien Thuong and Tuan-Nghia Phan (2018) A New Saponin with Anti-HIV-1 Protease Activity from Acacia pennata. Natural product communications 13(4): 411-414. (ISI/Scopus)
  11. Weerasinghe CAL, Bui BH, Vu TT, Nguyen THL, Phung BK, Nguyen VM, Pham VA, Cao VH, Phan TN* (2018) Leigh syndrome T8993C mitochondrial DNA mutation: Heteroplasmy and the first clinical presentation in a Vietnamese family. Mol. Med. Rep.17: 6919-6925. (ISI/Scopus)
  12. Hong-Loan Nguyen, Thu-Huyen Thi Tran, Thuong Thien Phuong and Tuan-Nghia Phan (2018) In vitro Inhibitory Effect of Lanostane Triterpenoids of Kadsura coccinea on the Human Immunodeficiency Virus Type-1 Protease. Indian J Pharm Sci 80(4):755-761. (ISI/Scopus)
  13. Nguyen THL, Tran TTH, Phuong TT, Phan TN* (2018). In vitro Inhibitory Effect of Two Lanostane Triterpenoids Isolated from Kadsura coccinea on the Protease Encoded by Human Immunodeficiency Virus Type 1. Ind. J. Pharmaceut. Sci. 80(4): 755-761.
  14. Nguyen TH, Nguyen TT, Pham TTH, Nguyen TNQ, Tran TM, Nguyen HA, Phan TN, BuiTVH, DaoTTH, Nguyen TVA (2018) Fate of carotenoid-producing Bacillus aquimaris SH6 colour spores in shrimp gut and their dose-dependent probiotic activities. Plos ONE, 13 (12): e0209341.
  15. Vu Xuan Tao, Ngo Tien Tho, Mai Thi Đam Linh, Bui Tri Thuc, Le Hong Điep, Bui Thi Viet Ha, Nguyen Quang Huy, Ngo Xuan Binh, Tran Van Tuan, 2018. A highly efficient Agrobacterium-tumefaciens-mediated transformation system for the postharvest pathogen Penicillium digitatum using DsRed and GFP to visualize citrus host colonization. Journal of Microbiological Methods 144:134-144. (ISI/Scopus).
  16. Trinh Tat Cuong, Giang Huy Diem, Tran Trung Doan, Nguyen Quang Huy, Nguyen Phuong and Hoang The Hung, 2018. Wedelolactone from Vietnamese Eclipta prostrata (L) L. protected zymosan-induced shock in mice. Iranian Journal of Pharmaceutical Research 17(2): 653-660.
  17. Cuong AM, Le Na NT, Thang PN, Diep TN, Thuy LB, Thanh NL, Thang ND*. Melanin-embedded materials effectively remove hexavalent chromium (CrVI) from aqueous solution. Environ Health Prev Med. 2018 Feb 23;23(1):9.
  18. Stephan Arni, Thi Hong Nhung Le (co-first author), Rik de Wijn, Martjin Dankers, Walter Weder, and Sven Hillinger (2018). Ex vivo multiplex profiling of protein tyrosine kinase activities in early stages of human lung adenocarcinoma, Oncotarget, 8(40), pp. 68599–68613.
  19. Khuyen Nguyen Thi, Quynh Ngoc Ho, Loc Thi Binh Xuan Do, Linh Thi Dam Mai, Duc-Ngoc Pham, Huyen Thi Thanh Tran, Diep Hong Le, Huy Quang Nguyen, Van-Tuan Tran, 2017. A new and efficient approach for construction of uridine/uracil auxotrophic mutants in the filamentous fungus Aspergillus oryzae using Agrobacterium tumefaciens-mediated transformation. World J Microbiol Biotechnol 33:107.
  20. Nguyen Dinh Thang*, Pham Ngoc Diep, Pham Thi Huong Lien, Le Thi Lien. Polygonum multiflorum root extract as a potential candidate for treatment of early graying hair. J Adv Pharm Technol Res. 2017; 8:8-13.
  21. Nguyen Dinh Thang*, Pham Thi Thu Huong, Bui Van Minh. Movement of BBAP from cytoplasm to nucleus decreases the metastatic ability of vemurafenib-resistant cells. Molecular Medicine. Mol Med Rep. 2017, 15 (1), 317-322.
  22. Hang T.L. Pham*, Lien T.T. Nguyen, Tuan A. Duong, Dung T.T Bui, Que T. Doan, Ha T.T Nguyen, Sabine Mundt (2017). Diversity and bioactivities of nostocacean cyanobacteria isolated from paddy soil in Vietnam. Systematic and Applied Microbiology, 40(8): 470 – 481.
  23. Mai Quynh Le, Hoa Phuong Thi Vu, Trang Thi Ngo, Hong Van Thi Nguyen, Thanh Trung Nguyen (2017) Osmotic stress acclimation of potato (Solanum tuberosum L.) HH7 variety seedlings induced by germination in sorbitol containing medium in-vitro. Journal of Chemical, Biological and Physical Sciences, Sec. B, Vol. 7, No. 2: 484 – 497.
  24. Pham KC, Tran TTH, Doan VC, L HP, Nguyen TVA, Nguyen HA, Huynh AH, Cutting SM, Phan TN* (2016). Protection of Penaeus monodon against white spot syndrome by continuous oral administration of a low concentration of Bacillus subtilis spores expressing the VP28 antigen. Lett. Appl. Microbiol. 64: 184-191. (ISI/Scopus).
  25. Ngo TH, Nguyen TTN, Nguyen QM, Tran VA, Do HTV, Nguyen HA, Phan TN, Nguyen TVA (2016) Screening of pigmented Bacillus aquimaris SH6 from the intestinal tracts of shrimp to develop a novel feed supplement for shrimp. J. Appl. Microbiol. 121: 1357-1372.
  26. Khuyen Thi K, Ngọc QH, Pham TH, PhanTN, Tran VT (2016). The construction and use of versatile binary vector carrying pyrG auxotrophic marker and flourecent reporter genes for Agrobacterium-mediated transformation of Aspergillus oryzae. W. J. Microbiol. Biotechnol. 32, 12, 204.
  27. Truong TH, Nguyen TVA, Nguyen VL, Pham VA, Phan TN *(2016) Screening of common point-mutations and discovery of new T14727C change in mitochondrial genome of Vietnamese encephalomyopathy patients. Mitochon. DNA 27(1):441-448.
  28. Vu Thi Thu, Hyoung-Kyu Kim, Le Thanh Long, To Thanh Thuy, Nguyen Quang Huy, Soon Ha Kim, Nari Kim, Kyung Soo Ko, Byoung Doo Rhee and Jin Han, 2016. NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts. The Korean Journal of Physiology & Pharmacology 20(3): 305-314.
  29. Ha Duc Chu, Quynh Ngoc Le, Huy Quang Nguyen, Dung Le, 2016. Genome-wide analysis of genes encoding methionine-rich proteins in Arabidopsis and soybean suggesting their roles in the adaptation of plants to abiotic stress. Journal of Genomics. Article ID 5427062.
  30. Ilmiawati C, Thang ND, Iida M, Maeda Masao, Ohnuma S, Yajima I, Ohgami N, Oshino R, Al Hossain A MM, Hiromasa N, Kato M. Limited effectiveness of household sand filters for removal of arsenic from well water in North Vietnam. J Water Health. 2016;14(6):1032-1040.
  31. Dang Thi Hoai Thanh, Nguyen Lai Thanh, Nguyen Dinh Thang*. Toxicological and melanin synthesis effects of Polygonum multiflorum root extracts on zebrafish embryos and human melanocytes. Biomedical Research and Therapy, 2016, 3(9), 808-818.
  32. Ngo Ngoc Trung, Nguyen Thi Tho, Bui Thi Thuy Dung, Hoang Thi My Nhung, Nguyen Dinh Thang*. Effects of ricin extracted from seeds of castor beans (ricinus communis) on cytotoxicity and tumorigenesis of melanoma cells. Biomedical Research and Therapy. 3(5): 633-644, 2016.
  33. Thang ND, Nghia PT, Yajima I, Kumasaka M, Kato M. (2016). Treatment of vemurafenib-resistant BRAFV600E melanoma cell by paclitaxel. Asian Pacific Journal of Cancer Prevention.16 (2), 699-705.
  34. Ohgami N, Thang ND, Yamanoshita O, Yajima I, Nakano C, Wenting W, Ohnuma S, Kato M. (2016). Carcinogenic risk of chromium, copper and arsenic in CCA-treated wood. Environmental Pollution. 206:456-460.
  35. Xuan Wang, Nhung Le, Annina Denoth-Lippuner, Yves Barral, and Ruth Kroschewski (2016). Asymmetric partitioning of transfected DNA during mammalian cell division. PNAS, 113(26), pp. 7177–82.

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